R. Curtis Rogers, MD

Senior Clinical Geneticist – Greenville Office

As Director of the Greenville Office of the Greenwood Genetic Center, Dr. Rogers is responsible for clinical genetics services in Upstate South Carolina. With four genetic counselors (three in Greenville and one in Spartanburg) and three clinical geneticists, the Greenville Office provides a wide range of services which encompass every age group.

These services include: Clinical evaluations of infants, children, and adults who have malformations and/or intellectual disabilities. Prenatal/preconceptional counseling for women with advanced maternal age, abnormal maternal serum screening, drug or medication exposures, or a known family history of malformations or intellectual disabilities.

Dr. Rogers has a special interest in the etiology and clinical aspects of skeltal dysplasias and craniofacial anomalies. He is also a clinician with the XLID evaluation and research team.

Selected Publications:

• Armour CM, Bulman DE, Jarinova O, Rogers RC, Clarkson KB, Dupont BR, Dwivedi A, Bartel FO, McDonell L, Schwartz CE, Boycott KM, Everman DB, Graham GE. 17p13.3 microduplications are associated with split-hand/foot malformation and long-bone deficiency (SHFLD). Eur J Hum Genet. 2011 Jun 1. [Epub ahead of print].

• Rollins JD, Sarasua SM, Phelan K, DuPont BR, Rogers RC, Collins JS. Growth in Phelan-McDermid syndrome. Am J Med Genet A. 2011 Sep;155A(9):2324-6.

• Lewis MEN, Gauderer MWL, Blackhurst DW, Rogers RC, and Cornett WR. Do patients with Down syndrome develop appendicitis?  J Ped Surg 46:197-99, 2011.

• Graham JM Jr, Clark RD, Moeschler JB, Rogers RC. Behavioral features in young adults with FG syndrome (Opitz-Kaveggia syndrome). Am J Med Genet C Semin Med Genet. Nov 15;154C(4):477-85.2010.
  
  
• Champion KJ, Bunag C, Estep AL, Jones JR, Bolt CH, Rogers RC, Rauen KA, Everman DB. Germline mutation in BRAF codon 600 is compatible with human development: de novo p.V600G mutation identified in a patient with CFC syndrome. Clin Genet. May;79(5):468-74, 2011.
  
  
• Lyons MJ, Graham JM Jr, Neri G, Hunter AG, Clark RD, Rogers RC, Moscarda M, Boccuto L, Simensen R, Dodd J, Robertson S, Dupont BR, Friez MJ, Schwartz CE, Stevenson RE.  Clinical Experience in the Evaluation of 30 Patients with a Prior Diagnosis of FG Syndrome.  J Med Genet. 46(1):9-13, 2009.
  
  
• Abidi FE, Holloway L, Moore CA, Weaver DD, Simensen RJ, Stevenson RE, Rogers RC, Schwartz CE.  Mutations in JARID1C are associated with X-linked mental retardation, short stature and hyperreflexia.  Journal of Medical Genetics 45:787-793, 2008.
  
  
• Rogers RC, Stevenson RE, Simensen RJ, Holden KR, Schwartz CE.  Finding new etiologies of mental retardation and hypotonia: X marks the spot.  Dev Med Child Neurol. 50(2):104-11, 2008.
  
  
• Rice G, Patrick T, Parmar R, Taylor CF, Aeby A, Aicardi J, Rogers RC, et al. Clinical and molecular phenotype of Aicardi-Goutieres syndrome.  Am J Hum Genet. 81(4):713-25, 2007.
  
  
• Risheg H, Graham JM Jr, Clark RD, Rogers RC, Opitz JM, Moeschler JB, Peiffer AP, May M, Joseph SM, Jones JR, Stevenson RE, Schwartz CE, Friez MJ. A recurrent mutation in MED12 leading to R961W causes Opitz-Kaveggia syndrome.Nat Genet. 39(4):451-3, 2007.
  
  
• Mathias G, Cowley R, Morales A, and Rogers RC: Congenital livedo reticularis and recurrent strokes in two unrelated young children.  Clin Pediatr 45(4):367-72, 2006.
  
  
• Crow YJ, Leitch A, Rogers RC, et al: Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutieres syndrome and mimic congenital viral brain infection.  Nat Genet. 38(8):910-6, 2006.
  
  
• Phelan MC. Stapleton GA, Rogers RC.  Terminal 22q13 deletion syndrome.  In: Management of Genetic Syndromes, ed 2. Wiley-Liss, Inc., New York, 2005.
  
  
• Rogers RC: Detection of a 3-beta-hydroxysteroid-delta(8)delta(7) isomerase (emapomil binding protein) mutation in a patient with chondrodysplasia punctata. Proc Greenwood Genetic Center 17-22, 2003.
  
  
• de Mollerat XJ, Everman DB, Morgan CT, Clarkson KB, Rogers RC, et al. P63 mutations are not a major cause of non-syndromic split hand/foot malformation. J Med Genet 40:55-61, 2003.
  
  
• Phelan MC, Rogers RC, et al. Velocardiofacial syndrome in an unexplained XX male. Am J Med Genet 116:77-9, 2003.
  
  
• Phelan MC, Rogers RC, Saul RA, Stapleton GA, Sweet K, McDermid H, Shaw SR, Claytor J, Willis J, Kelly DP. 22q13 deletion syndrome. Am J Med Genet 101:91-9, 2001.
  
  
• Boyadjiev SA, Jabs EW, LaBuda M, Jamal JE, Torbergsen T, Ptacek LJ, Rogers RC, et al. Linkage analysis narrows the critical region for oculodentodigital dysplasia to chromosome 6q22-q23. Genomics 58:34-40, 1999.
  
  
• Hane BG, Rogers RC and Schwartz C. Germline mosaicism in X-linked myotubular myopathy. Clin Genet 56:77-81, 1999.
  
  
• Graham JM, Superneau D, Rogers RC, et al. Clinical and behavioral characteristics in FG syndrome. Am J Med Genet 85:470-475, 1999.
  
  
• Graham JM, Tackels D, Dibbern K, Superneau D, Rogers RC, et al: FG syndrome. Report of three new families with linkage to Xq12-q22.1. Am J Med Genet 80:145-56, 1998.
  
  
• Rogers RC, Houk C, Jones SJ, Blackburn W.  Lethal skeletal dysplasias. Proc Greenwood Genet Cntr 16:58-68, 1997.
  
  
• Brown A, Phelan MC, Patil S, Crawford EC, Rogers RC, Schwartz C.  Two patients with duplication of 17p11.2: The reciprocal of the Smith-Magenis deletion? Am J Med Genet 63:373-377, 1996.
  
  
• Robson WML, Leung AKC, Rogers RC.  Unilateral renal agenesis. Adv Pediatr 42:575-592, 1995.
  
  
• Anderson WG, Rogers RC.  Hand-foot-uterus syndrome versus ulnar-mammary syndrome - A patient with overlapping phenotypic features. Proc Greenwood Genet Cntr 14:17-20, 1995.
  
  
• Phelan MC, Rogers RC, et al.  Albright hereditary osteodystrophy and del(2)(q37.3) in four unrelated individuals. Am J Med Genet 58:1-7, 1995.
  
  
• Saul RA, Rogers RC, et al.  Brachmann-de Lange syndrome: Diagnostic difficulties posed by the mild phenotype. Am J Med Genet 47:999-1002, 1993.
  
  
• Phelan MC, Rogers RC, et al.  Cytogenetic, biochemical, and molecular analysis of a 22q13 deletion. Am J Med Genet 43:872-876, 1992.
  
  
• Rogers RC et al.  Tricho-rhino-phalangeal syndrome with exostoses (Langer-Giedion syndrome). Proc Greenwood Genet Cntr 6:44-47, 1987.