R. Curtis Rogers, MD

Senior Clinical Geneticist – Greenville Office

CurtisRogersAs Director of the Greenville Office of the Greenwood Genetic Center, Dr. Rogers is responsible for clinical genetics services in Upstate South Carolina. With five genetic counselors and three clinical geneticists, the Greenville Office provides a wide range of services which encompass every age group.

These services include: Clinical evaluations of infants, children, and adults who have birth defects and/or intellectual disabilities, lysosomal storage disorders, and neuromuscular disorders; and prenatal/preconceptional counseling for women with advanced maternal age, abnormal maternal serum screening, drug or medication exposures, or a known family history of malformations or intellectual disabilities.

Dr. Rogers has a special interest in the etiology and clinical aspects of skeletal dysplasias and craniofacial anomalies. He is also a clinician with the XLID evaluation and research team.

Selected Publications:

  • Louie RJ, Tan QKG, Gilner JB, Rogers RC, Younge N, Wechsler SB, McDonald MT, Gordon B, Saski CA, Jones JR, Chapman SJ, Stevenson RE, Sleasman JW, Friez MJ.  Novel Alterations in the FOXP3 Gene in Fetuses with Echogenic Bowel and Skin Desquamation Identified by Ultrasound.  Am J Med Genet. 2017;173A:1219–1225.

  • Le Goff C, Rogers C, Le Goff W, Pinto G, Bonnet D, Chrabieh M, Alibeu O, Nistchke P, Munnich A, Picard C, Cormier-Daire V.  Heterozygous Mutations in MAP3K7, Encoding TGF-β-Activated Kinase 1, Cause Cardiospondylocarpofacial Syndrome.  Am J Hum Genet. 2016 Aug 4;99(2):407-13.  

  • Pierce SB, Gulsuner S,  Stapleton GA, Walsh T, Lee MK, Mandell JB, Morales A,  Klevit RE, King MC,  and Rogers RC.  Infantile onset spinocerebellar ataxia caused by compound heterozygosity for Twinkle mutations and modeling of Twinkle mutations causing recessive disease. Cold Spring Harb Mol Case Stud. 2016 Jul;2(4). 

  • Byrne S, Jansen L, U-King-Im JM, Siddiqui A, Lidov HG, Bodi I, Smith L, Mein R, Cullup T, Dionisi-Vici C, Al-Gazali L, Al-Owain M, Bruwer Z, Al Thihli K, El-Garhy R, Flanigan KM, Manickam K, Zmuda E, Banks W, Gershoni-Baruch R, Mandel H, Dagan E, Raas-Rothschild A, Barash H, Filloux F, Creel D, Harris M, Hamosh A, Kölker S, Ebrahimi-Fakhari D, Hoffmann GF, Manchester D, Boyer PJ, Manzur AY, Lourenco CM, Pilz DT, Kamath A, Prabhakar P, Rao VK, Rogers RC, Ryan MM, Brown NJ, McLean CA, Said E, Schara U, Stein A, Sewry C, Travan L, Wijburg FA, Zenker M, Mohammed S, Fanto M, Gautel M, and Jungbluth H.  EPG5-related Vici syndrome: a paradigm of neurodevelopmental disorders with defective autophagy.  Brain. 2016 Mar;139(Pt 3):765-81.

  • Ramappa M, Wilson ME, Rogers RC, Trivedi RH. Brittle Cornea Syndrome: A case report and comparison with Ehlers Danlos syndrome. J Am Assoc Ped Ophthalmol and Strabismus 18(5):509-511. October 2014.
  • Sarasua SM, Boccuto L, Sharp JL, Dwivedi A, Chen CF, Rollins JD, Rogers RC, Phelan K, Dupont BR. Clinical and genomic evaluation of 201 patients with Phelan-McDermid syndrome. Hum Genet. 133:847-859, 2014.

  • Hodge JC, Mitchell E, Pillalamarri V, Toler TL, Bartel F, Kearney HM, Zou YS, Tan WH, Hanscom C, Kirmani S, Hanson RR, Skinner SA, Rogers RC, Everman DB, Boyd E, Tapp C, Mullegama SV, Keelean-Fuller D, Powell CM, Elsea SH, Morton CC, Gusella JF, DuPont B, Chaubey A, Lin AE, and Talkowski ME. Disruption of MBD5 contributes to a spectrum of psychopathology and neurodevelopmental abnormalities. Molecular Psychiatry 19(3):368-79, 2014.

  • Hunter AGW, Graham JM, Neri G, Rogers RC, Stevenson RE, Turner G, and Freiz MJ. The Intellectual Disabilities Evaluation and Advice System (IDEAS): Outcome of the first 55 cases. Am J Med Genet Part A. 164(5):1102-17, 2014.

  • Sarasua SM, Dwivedi A, Boccuto L, Chen CF, SharpJL, Rollins JD, Collins JS, Rogers RC, Phelan MC, and DuPont BR. 22q13.2q13.32 genomic regions associated with severity of speech delay, developmental delay, and physical features in Phelan–McDermid syndrome. Genetics in Medicine 16(4):318-28, 2014.

  • Rogers RC, Abidi FE. Coffin-Lowry Syndrome. 2002 Jul 16 [Updated 2014 Mar 27]. In: Pagon RA, Adam MP, Bird TD, et al., editors. GeneReviews [Internet]. Seattle (WA): University of Washington, Seattle; 1993-2014. Available from: http://www.ncbi.nlm.nih.gov/books/NBK1346/

  • Stevenson RE, Schwartz CE, and Rogers RC. Malformations Among the X-linked Intellectual Disability Syndromes. Am J Med Genet, 161(11):2741-49, 2013.

  • Cullup T, Kho AL, Dionisi-Vici C, Brandmeier B, Smith F, Urry Z, Simpson MA, Yau S, Bertini E, McClelland V, Al-Owain M, Koelker S, Koerner C, Hoffmann GF, Wijburg FA, ten Hoedt AE, Rogers RC, Manchester D, Miyata R, Hayashi M, Said E, Soler D, Kroisel PM, Windpassinger C, Filloux FM, Al-Kaabi S, Hertecant J, Del Campo M, Buk S, Bodi I, Goebel HH, Sewry CA, Abbs S, Mohammed S, Josifova D, Gautel M, and Jungbluth H. Recessive mutations in EPG5 cause Vici syndrome, a multisystem disorder with defective autophagy Nature Genetics 45:83-87, 2013.

  • Stevenson RE, Schwartz CE, and Rogers RC (2012). Atlas of X-linked Intellectual Disability Syndromes (2nd edition), Oxford Press.

  • Simensen RJ, Rogers RC, Collins JS, Abidi F, Schwartz CE, Stevenson RE. Short-term memory deficits in carrier females with KDM5C mutations. Genet Couns. June 2012;23(1):31-40.

  • Doherty D, Chudley AE, et al, Rogers RC. GPSM2 Mutations Cause the Brain Malformations and Hearing Loss in Chudley-McCullough Syndrome. Am J Hum Gen 2012, June 8; 90(6):1088-93.

  • Stevenson RE, Holden KR, Rogers RC, Schwartz CE. Seizures and X-linked intellectual disability. Europ J Med Genet 2012 Feb:307-312.

  • Boyden ED, Campos-Xavier AB, Kalamajski S, Cameron TL, Suarez P, Tanackovich G, Andria G, Ballhausen D, Briggs MD, Hartley C, Cohn DH, Davidson HR, Hall C, Ikegawa S, Jouk PS, König R, Megarbané A, Nishimura G, Lachman RS, Mortier G, Rimoin DL, Rogers RC, Rossi M, Sawada H, Scott R, Unger S, Valadares ER, Bateman JF, Warman ML, Superti-Furga A, Bonafé L. Recurrent dominant mutations affecting two adjacent residues in the motor domain of the monomeric kinesin KIF22 result in skeletal dysplasia and joint laxity. Am J Hum Genet. 2011 Dec 9;89(6):767-72.

  • Sarasua SM, Dwivedi A, Boccuto L, Rollins JD, Chen CF, Rogers RC, Phelan K, DuPont BR, Collins JS. Association between deletion size and important phenotypes expands the genomic region of interest in Phelan-McDermid syndrome (22q13 deletion syndrome). J Med Genet 2011 Nov;48(11):761-6.

  • Armour CM, Bulman DE, Jarinova O, Rogers RC, Clarkson KB, Dupont BR, Dwivedi A, Bartel FO, McDonell L, Schwartz CE, Boycott KM, Everman DB, Graham GE. 17p13.3 microduplications are associated with split-hand/foot malformation and long-bone deficiency (SHFLD). Eur J Hum Genet. 2011 Jun 1. [Epub ahead of print].

  • Rollins JD, Sarasua SM, Phelan K, DuPont BR, Rogers RC, Collins JS. Growth in Phelan-McDermid syndrome. Am J Med Genet A. 2011 Sep;155A(9):2324-6.

  • Phelan MC. Stapleton GA, Rogers RC. Terminal 22q13 deletion syndrome. In: Management of Genetic Syndromes, ed 3. Wiley-Liss, Inc., New York, 2010.

  • Graham JM Jr, Clark RD, Moeschler JB, Rogers RC. Behavioral features in young adults with FG syndrome (Opitz-Kaveggia syndrome). Am J Med Genet C Semin Med Genet. Nov 15;154C(4):477-85.2010.

  • Lyons MJ, Graham JM Jr, Neri G, Hunter AG, Clark RD, Rogers RC, Moscarda M, Boccuto L, Simensen R, Dodd J, Robertson S, Dupont BR, Friez MJ, Schwartz CE, Stevenson RE. Clinical Experience in the Evaluation of 30 Patients with a Prior Diagnosis of FG Syndrome. J Med Genet. 46(1):9-13, 2009.

  • Abidi FE, Holloway L, Moore CA, Weaver DD, Simensen RJ, Stevenson RE, Rogers RC, Schwartz CE. Mutations in JARID1C are associated with X-linked mental retardation, short stature and hyperreflexia. Journal of Medical Genetics 45:787-793, 2008.

  • Rogers RC, Stevenson RE, Simensen RJ, Holden KR, Schwartz CE. Finding new etiologies of mental retardation and hypotonia: X marks the spot. Dev Med Child Neurol. 50(2):104-11, 2008.

  • Rice G, Patrick T, Parmar R, Taylor CF, Aeby A, Aicardi J, Rogers RC, et al. Clinical and molecular phenotype of Aicardi-Goutieres syndrome. Am J Hum Genet. 81(4):713-25, 2007.

  • Crow YJ, Leitch A, Rogers RC, et al: Mutations in genes encoding ribonuclease H2 subunits cause Aicardi-Goutieres syndrome and mimic congenital viral brain infection. Nat Genet. 38(8):910-6, 2006.

  • de Mollerat XJ, Everman DB, Morgan CT, Clarkson KB, Rogers RC, et al. P63 mutations are not a major cause of non-syndromic split hand/foot malformation. J Med Genet 40:55-61, 2003.

  • Phelan MC, Rogers RC, Saul RA, Stapleton GA, Sweet K, McDermid H, Shaw SR, Claytor J, Willis J, Kelly DP. 22q13 deletion syndrome. Am J Med Genet 101:91-9, 2001.

  • Boyadjiev SA, Jabs EW, LaBuda M, Jamal JE, Torbergsen T, Ptacek LJ, Rogers RC, et al. Linkage analysis narrows the critical region for oculodentodigital dysplasia to chromosome 6q22-q23. Genomics 58:34-40, 1999.

  • Hane BG, Rogers RC and Schwartz C. Germline mosaicism in X-linked myotubular myopathy. Clin Genet 56:77-81, 1999. Graham JM, Superneau D, Rogers RC, et al. Clinical and behavioral characteristics in FG syndrome. Am J Med Genet 85:470-475, 1999.

  • Graham JM, Tackels D, Dibbern K, Superneau D, Rogers RC, et al: FG syndrome. Report of three new families with linkage to Xq12-q22.1. Am J Med Genet 80:145-56, 1998.

  • Rogers RC, Houk C, Jones SJ, Blackburn W. Lethal skeletal dysplasias. Proc Greenwood Genet Cntr 16:58-68, 1997.

  • Brown A, Phelan MC, Patil S, Crawford EC, Rogers RC, Schwartz C. Two patients with duplication of 17p11.2: The reciprocal of the Smith-Magenis deletion? Am J Med Genet 63:373-377, 1996.

  • Phelan MC, Rogers RC, et al. Albright hereditary osteodystrophy and del(2)(q37.3) in four unrelated individuals. Am J Med Genet 58:1-7, 1995.

  • Saul RA, Rogers RC, et al. Brachmann-de Lange syndrome: Diagnostic difficulties posed by the mild phenotype. Am J Med Genet 47:999-1002, 1993.

  • Phelan MC, Rogers RC, et al. Cytogenetic, biochemical, and molecular analysis of a 22q13 deletion. Am J Med Genet 43:872-876, 1992.

     

Contact Information

Office (864) 250-7949 ext. 102
Fax (864) 250-9582
crogers@ggc.org
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Education

  • M.D., Medical University of South Carolina, 1980
  • Resident (Pediatrics), Greenville Hospital System, Greenville, SC, 1983
  • Fellow (Clinical Genetics), Greenwood Genetic Center, Greenwood, SC, 1985