Taraka Donti, PhD

Assistant Director - Biochemical Genetics Laboratory

TarakaDontiDr. Donti joined GGC in 2016. He has a special interest in biochemical genetics and mitchondrial biology. The focus of his postdoctoral research was to identify and characterize genes that are involved in mitochondrial disorders. The mitochondrial proteome is encoded by both nuclear genome and mitochondrial genome. Any deficiency in either genome can lead to defective mitochondria resulting in devastating multi-systemic disorders. Mitochondrial disorders are complex disorders and are difficult to diagnose and to treat.

At GGC, Dr. Donti is involved in establishing and validating diagnostic tests for mitochondrial disorders. He is a member of the American College of Medical Genetics, American Society of Human Genetics and the Society of Inherited Metabolic Disease.

Selected Publications

  • Taraka R Donti, Patrick R Blackburn, Paldeep S Atwal (2016) Holocarboxylase synthetase deficiency pre and post newborn screening. Mol Genet Metab Rep. 2016 Apr 6;7:40-4. PMID:27114915
  • Roa Sadat, Emanuele Barca, Ruchi Masand, Taraka R Donti, Ali Naini, Darryl C DeVivo, Salvatore DiMauro, Neil A Hanchard (2016) Functional Cellular Analyses Reveal Energy Metabolism Defect and Mitochondrial DNA Depletion in a Case of Mitochondrial Aconitase Deficiency. Mol Genet Metab. 2016 May;118(1):28-34. PMID:26992325
  • Marcus J. Miller, Bret L. Bostwick, Adam D. Kennedy, Taraka R Donti, Qin Sun, V. Reid Sutton, and Sarah H. Elsea (2016) Chronic oral L-carnitine supplementation drives marked plasma TMAO elevations in patients with organic acidemias despite dietary meat restrictions. JIMD Rep. 2016 Mar 3. PMID:26936850
  • Jun Hyoung Park, Sajna Vithayathil, Santosh Kumar, Pi-Lin Sung, Lacey Elizabeth Dobrolecki, Vasanta Putluri, Vadiraja B. Bhat, Salil Bhowmik, Vineet Gupta, Kavisha Arora, Danli Wu, Efrosini Tsouko, Yiqun Zhang, Suman Maity, Taraka R. Donti, Brett H. Graham, Daniel E. Frigo, Cristian Coarfa, Patricia Yotnda, Nagireddy Putluri, Arun Sreekumar, Michael T Lewis, Chad J. Creighton, Lee-Jun C. Wong & Benny Abraham Kaipparettu (2016) Fatty acid oxidation driven Src links mitochondrial energy reprogramming to the regulation of oncogenic properties in triple negative breast cancer. Cell Rep. 2016 Mar 8;14(9):2154-65. PMID:26923594
  • San-Pin Wu, Chung-Yang Kao, Leiming Wang, Chad Creighton, Jin Yang, Taraka Donti, Romain Harmancey, Hernan G. Vasquez, Brett Graham, Hugo Bellen, Heinrich Taegtmeyer, Ching-Pin Chang, Ming-Jer Tsai, and Sophia Tsai (2015) Increased COUP-TFII Expression in Adult Hearts Induces Mitochondrial Dysfunction Resulting in Heart Failure. Nat Commun. 2015 Sep 10;6:8245. doi: 10.1038/ncomms9245. PMID: 26356605
  • Jaiswal M, Haelterman NA, Sandoval H, Xiong B, Donti T, Kalsotra A, et al. (2015) Impaired Mitochondrial Energy Production Causes Light Induced Photoreceptor Degeneration Independent of Oxidative Stress. PLoS Biol 13(7): e1002197. doi:10.1371/journal.pbio.1002197. PMID: 26176594
  • Paldeep S. Atwal, Taraka R. Donti, Aaron L. Cardon, C. A. Bacino, Qin Sun, L. Emrick, V. Reid Sutton, and Sarah H. Elsea (2015) Aromatic L-Amino Acid Decarboxylase Deficiency Diagnosed by Clinical Metabolomic Profiling of Plasma. Molecular Genetics and Metabolism 2015 Jun-Jul;115(2-3):91-4. PMID: 25956449
  • Arnaud Besse, Ping Wu, Francesco Bruni, Taraka Donti, Brett H. Graham, William J. Craigen, Robert McFarland, Paolo Moretti, Seema Lalani, Kenneth L. Scott, Robert W. Taylor, Penelope E. Bonnen (2015) The GABA Transaminase, ABAT, Is Essential for Mitochondrial Nucleoside Metabolism. Cell Metabolism 21, 417–427. PMID: 25738457

 

Contact Information

Office (864) 388-1043
Fax (864) 941-8133
tdonti@ggc.org

Education

  • M.Sc, Applied Chemistry, Institute of Chemical Sciences, Devi Ahilya University, Indore, India, 1998
  • MS, Biotechnology, Stephen F Austin State University, Nacogdoches, Texas, 2002
  • Ph.D, Molecular and Cellular Medicine, Texas A&M - Health Science Center, College Station, Texas, 2008
  • Postdoctoral Associate, Molecular & Human Genetics, Baylor College of Medicine, 2008-2014
  • ABMGG Biochemical Laboratory Fellow, Baylor College of Medicine, 2014-2016
  • Assistant Director, Biochemical Genetics Laboratory, Greenwood Genetic Center, 2016-present