Kristen J. Champion, PhD

Assistant Director – Molecular Diagnostic Laboratory

Dr. Champion came to the Greenwood Genetic Center in 2008 to complete a clinical molecular genetics fellowship in the Molecular Diagnostic Laboratory. Upon completion of her fellowship, she became the Assistant Director of the Molecular Diagnostic Laboratory. The Molecular Diagnostic Laboratory specializes in the diagnosis of mental retardation, muscular dystrophies, skeletal dysplasias, and many other genetic conditions. Dr. Champion’s primary responsibilities include the interpretation of molecular test results, development and implementation of new molecular diagnostic assays, and involvement in various clinical research projects throughout the GGC.

  Selected Publications

• Champion KJ, Bunag C, Estep AL, Jones JR, Bolt CH, Rogers RC, Rauen KA, Everman DB. Germline mutation in BRAF codon 600 is compatible with human development: de novo p.V600G mutation identified in a patient with CFC syndrome. Clin Genet. 2011 May;79(5):468-74.
• Champion KJ, Basehore MJ, Wood T, Destrée A, Vannuffel P, Maystadt I. Identification and characterization of a novel homozygous deletion in the alpha-N-acetylglucosaminidase gene in a patient with Sanfilippo type B syndrome (mucopolysaccharidosis IIIB). Mol Genet Metab. 2010 May;100(1):51-6.
• Champion KJ, Guinea M, Dammai V, Hsu T. Endothelial function of von Hippel-Lindau tumor suppressor gene: control of fibroblast growth factor receptor signaling. Cancer Res. 2008 Jun 15;68(12):4649-57.
• Chintalapudi MR, Markiewicz M, Kose N, Dammai V, Champion KJ, Hoda RS, Trojanowska M, Hsu T. Cyr61/CCN1 and CTGF/CCN2 mediate the proangiogenic activity of VHL-mutant renal carcinoma cells. Carcinogenesis. 2008 Apr;29(4):696-703.
• Adereth Y, Champion KJ, Hsu T, Dammai V. Site-directed mutagenesis using Pfu DNA polymerase and T4 DNA ligase. Biotechniques. 2005 Jun;38(6):864-868.