Metabolic Advanced Practice Provider Fellowship

The Greenwood Genetic Center Metabolic Advanced Practice Provider (GGC MAPP) Fellowship is a 12-month training program designed to prepare a Nurse Practitioner or Physician Assistant to assist in the diagnosis and medical management of individuals with Lysosomal Storage Disorders (LSDs). Applicants will have a degree from an accredited graduate program and either NP or PA certification.

GGC currently provides clinical diagnostic evaluations across the entire state of South Carolina with 13 physicians, 15 genetic counselors, 3 metabolic dieticians, and 1 neuropsychologist. Patients with confirmed LSDs receive disease-specific therapy (when available), care coordination, and specialized laboratory services.

The trainee will be mentored by Dr. R. Curtis Rogers in the Greenville GGC office, where the majority of LSD patients are followed. The MAPP Fellow will participate in clinical visits for patients with known or suspected LSDs seen in all GGC offices (Charleston, Columbia, Florence, Greenville, and Greenwood, SC). In addition, the MAPP Fellow will attend weekly general metabolic clinic and other Greenville-area multidisciplinary clinics.

The academic training will build a broad base of knowledge in clinical genetics coordinated with other clinical and laboratory trainees at GGC. The Fellow will attend the Graduate Course (a 19 week, 48 hour course), weekly conferences, monthly case reviews, and monthly seminars. The fellow will present at these events regularly. Dr. Rogers and other faculty will provide periodic didactic sessions pertaining specifically to LSD diagnosis and treatment. A rotation in the GGC Biochemical Genetics Laboratory will allow insight into the diagnostic and monitoring studies used in the care of patients with LSDs.

The MAPP Fellow will be exposed to research in the field of LSDs by attending the 2019 WORLD Symposium and working with the local site PI for the Sanofi Genzyme Rare Disease Registries and the Hunter Outcome Survey. An original research project is anticipated, with results presented at an annual meeting such as the Southeastern Regional Genetics Group (SERGG).

By the end of the program, the MAPP Fellow will be capable of working with a team of healthcare providers to improve early diagnosis, recognize at-risk relatives, and order laboratory studies, evaluations, and primary therapies that lead to optimal outcomes for patients with lysosomal disorders in SC. GGC would hope to offer full time employment to the individual who successfully completed this training.

Laboratory Genetics and Genomics Fellowship

Candidates with an M.D. or a Ph.D. degree in one of the basic sciences may enter this program. The Laboratory Genetics and Genomics (LGG) fellowship is a three year program that allows the trainee to gain competence in performing and interpreting cytogenetic analysis relevant to the diagnosis and management of chromosome disorders, as well as in all molecular analyses relevant to the diagnosis of genetic disorders at the gene level. The trainee will also gain research experience by participating in on-going research projects and by conducting independent research.

Training is conducted through both the DNA Diagnostic and Cytogenetics Laboratories of the Greenwood Genetic Center. The DNA Diagnostic Laboratory handles blood, amniocytes and CVS tissue samples for molecular analysis. The trainee will gain expertise in DNA and RNA isolation, PCR, Southern blotting, RFLP analysis, Multiplex Ligation-Dependent Probe Amplification (MLPA), Pyrosequencing, and DNA sequencing – both Sanger and NextGen. The Cytogenetics Laboratory provides training in routine G-banded analysis, special staining such as C-banding, silver staining, R-banding, and Q-banding, fluorescence in situ hybridization (FISH) and array CGH for the diagnosis of microdeletion and microduplication syndromes, the detection of aneuploidy in uncultured cells, and the identification of marker chromosomes.

At completion of the program, LGG Fellows will possess the skills required for certification by the ABMGG, including competence in:

  • Supervising and directing the operations of a clinical cytogenetics and/or molecular genetics diagnostic laboratory, including technical experience and knowledge in quality control and quality assessment procedures.
  • Performing a variety of cytogenetic and molecular diagnostic assays;
  • Understanding of the heterogeneity, variability, and natural history of chromosome and molecular genetic disorders;
  • Diagnostic and interpretive skills in a wide range of clinical molecular genetics and cytogenetics problems.
  • Communicating molecular and cytogenetic diagnostic laboratory results in the capacity of a consultant to medical genetics professionals and other clinicians, and directly to patients in concert with other professional staff.

By attending weekly clinic conference, weekly laboratory conference, and monthly state-wide case review, the trainee will interact with clinical geneticists, genetic counselors and others who refer patients for cytogenetic and/or molecular testing. This interaction will allow discussion of pertinent clinical features corresponding with laboratory findings and will permit the opportunity for discussion of counseling issues such as long term prognosis, family studies, recurrence risks, and additional laboratory testing. In addition, the trainee is required to participate in a core course in Advanced Human Genetics by attending all lectures and by limited teaching responsibilities.

Training Programs

The Greenwood Genetic Center operates South Carolina's only Medical Genetics training program and is one of 44 accredited programs in the nation to offer training in all specialty areas.

The Center's Postdoctoral Genetics Training Program is designed for individuals with an MD or PhD degree seeking academic, clinical, and research careers in human and medical genetics. The programs are accredited by the Accreditation Council for Graduate Medical Education (MD) and the American Board of Medical Genetics and Genomics (PhD). These training programs last two to three years. Clinical, as well as research competence is stressed with opportunities available for the trainee in all areas of genetics.

A new program has been added to begin in 2018 - Metabolic Advanced Practice Provider Fellowship designed for Nurse Practitioners and Physican's Assistants.

For additional information on any of our Medical Genetics Training programs contact Dr. Leta Tribble at (888)442-4363 or (864)943-4170 or This email address is being protected from spambots. You need JavaScript enabled to view it. .

Clinical Biochemical Genetics

The clinical biochemical genetics fellowship program will allow the trainee to perform and interpret biochemical analyses. Instruction will be given on basic and advanced diagnostic techniques relevant to the diagnosis and management of human biochemical genetic diseases. Experience with a broad range of testing and disorders including follow-up newborn screening, lysosomal storage disorders, congenital disorders of glycosylation, fatty acid oxidation disorders, organic acidurias and creatine biosynthesis disorders will be covered. Training will also include a basic understanding of the integration of molecular data into biochemical genetic testing.

An individual completing the fellowship program will possess the skills required for certification by the ABMGG including:

  • The ability to supervise and direct the operations of a clinical biochemical genetic diagnostic laboratory.
  • The application of biochemical techniques to the diagnosis and management of genetic biochemical/metabolic diseases.
  • The etiology, pathogenesis, clinical manifestations and management of human inherited biochemical conditions.
  • The ability to appropriately interpret and communicate biochemical laboratory results as a consultant to other clinicians, genetic counselors or directly to patients in cooperation with a clinical staff.

Student Opportunities

High School Student Shadowing Program

The faculty and staff of GGC believe that students at the high school level should be encouraged and exposed to the vast opportunities in the field of genetics. Qualified students can experience a one-day shadowing opportunity at GGC in the areas of diagnostic laboratory testing, research and clinical genetics.

Contact Leta Tribble, PhD at This email address is being protected from spambots. You need JavaScript enabled to view it. or (864)943-4170 for more information.

Summer Internship Program for Undergraduate Students

The Greenwood Genetic Center offers a summer internship program for highly qualified college students. The program provides seven stipend positions each summer. Each internship lasts 8-10 weeks. Preference is given to rising juniors and seniors; however all applications will be reviewed and considered. Potential candidates will be contacted directly by a GGC faculty member for interviews.

Application process is by electronic submission

  • Complete the application form Download
  • Attach a cover letter for introductory information and your area(s) of interest
  • Attach a brief resume that includes work experiences and completed coursework

Study Participation

Eligible participants include individuals from birth to 60 years who have had genetic testing and have a documented molecular diagnosis of Angelman syndrome OR patients with a clear clinical diagnosis of Angelman syndrome who do not have a known molecular defect.

For more information, see the Angelman syndrome study fact sheet or contact This email address is being protected from spambots. You need JavaScript enabled to view it. , study coordinator.