Wesley Patterson, MSPA, PA-C

Physician Assistant

Wesley PattersonWesley Patterson, PA-C, is a physician assistant who rejoined the Greenwood Genetic Center in January 2018. He is involved in the evaluation and treatment of genetic disorders in individuals of all ages.

Wesley received his Bachelor of Science degree in Animal and Veterinary Sciences from Clemson University in 2009 and his Master of Science degree in Physician Assistant from Jefferson College of Health Sciences in 2014. Between undergraduate and graduate school, he worked in the molecular diagnostic laboratory as a laboratory technologist at the Greenwood Genetic Center for two years.

Wesley is certified by the National Commission on Certification of Physician Assistants (2014), and he holds memberships in the American Academy of Physician Assistants and the South Carolina Academy of Physician Assistants.

 

Juan Bolanos

JuanBolanosBioinformatics Analyst

Juan Bolanos joined GGC's Diagnostic Laboratory bioinformatics team in 2017 with a focus on utilizing bioinformatic tools and software to analyze next generation sequencing data.

Rahul Deshpande, PhD

Mass Spectrometry Specialist

RahulDeshpande

Xuemei Shi, MD, PhD

Clinical Molecular Specialist

Xuemei ShiDr. Shi joined the GGC Molecular Diagnostic Laboratory as a Clinical Molecular Specialist in 2017. She is mainly responsible for data review of clinical testing and research and genetic variant interpretation. Additional responsibilities inlcude investigating novel testing methodologies and participating in the development of new diagnostic assays and procedures.

Dr. Shi is certified in Molecular Biology (MB) by the American Society of Clinical Pathology. Her clinical research work in the Molecular Diagnostic Lab at the University of Texas M.D. Anderson Cancer Center focused on identifying low prevalence mutations using circulating cell free DNA for cancer diagnosis. Her postdoctoral research included signaling pathway studies of the central regulation of glucose homeostasis through gut-brain peptide by using knockout and pharmacogenomics mouse models and metabolomics study by using 3D-cultivated mini-gut model. She has numerous publications in prestigious journals, has been awarded by the American Physiological Society, has one funded grant (2016-2019), and two patents being filed.

Selected Publications

  • Shi X*, Chacko S, Li F, Li D, Burrin D, Chan L, Guan X. Acute activation of GLP-1-expressing neurons promotes glucose homeostasis and insulin sensitivity. Mol Metab. 2017 Nov; 6(11): 1350-1359 (* Corresponding author)

  • Shi X, Zhou F, Li X, Chang B, Li D, Wang Y, Tong Q, Xu Y, Fukuda M, Zhao JJ, Li D, Burrin DG, Chan L, Guan X. Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons. Cell Metab. 2013 Jul 2; 18 (1): 86-98. PMID: 23823479

  • Guan X, Shi X (Co-first author), Li X, Chang B, Wang Y, Li D, Chan L. GLP-2 receptor in POMC neurons suppresses feeding behavior and gastric motility. Am J Physiol Endocrinol Metab. 2012 Oct 1;303 (7): E853-64. PMID: 22829581

  • Wang Y, Shi X (Co-first author), Qi J, Li X, Uray K, Guan X. SIRT1 inhibits the mouse intestinal motility and epithelial proliferation. Am J Physiol Gastrointest Liver Physiol. 2012 Jan 15; 302 (2): G207-17. PMID: 22038824

  • Shi X, Li X, Wang Y, Zhang K, Zhou F, Chan L, Li D, Guan X. Glucagon-like peptide-stimulated protein synthesis through the PI 3-kinase-dependent Akt-mTOR signaling pathway. Am J Physiol Endocrinol Metab. 2011 Mar; 300 (3): E554-63. PMID: 21177288

Heather Davis, RN

Clinical Research Nurse

HeatherDavisHeather joined the Greenwood Genetic Center's Division of Research in 2017 to broaden her skill range and learn more about how nursing relates to genetics. After attending Lander University, Heather obtained an Associate in Arts (AA), followed by an Associate Degree in Nursing (ADN) from Piedmont Technical College. She began her career as an RN in the Neonatal Intensive Care Unit at Self Regional Healthcare in Greenwood, SC. She then worked as a Vascular Access RN at AnMed Health in Anderson, SC and Saint Francis Hospital in Greenville, SC where she became Vascular Access Board Certified.

Study Participation

Eligible participants include individuals at all ages who have had complete MECP2 gene analysis and have the clinical diagnosis of classic or variant Rett syndrome, with or without mutations in the gene OR individuals without clinical Rett syndrome but with MECP2 mutations.

For more information, see the Rett syndrome study fact sheet or contact This email address is being protected from spambots. You need JavaScript enabled to view it. , study coordinator.