Prenatal Chromosome Analysis – Amniotic Fluid

Clinical info Routine chromosomes and FISH trisomy screen for 13, 18, and 21 are available for prenatal samples.
Indications
  • Couples at increased risk of having infants with abnormal chromosomes
  • Advanced maternal age - 35 years or older
  • Previous child with a chromosome disorder such as Down syndrome
  • One member of the couple is known to carry a chromosome rearrangement
  • In certain cases, relatives of a child with a chromosome disorder
  • Couples at risk for having children with X-linked disorders for which molecular testing may not be available.
  • Pregnancies at increased risk of chromosome defects due to finding of fetal defects on ultrasound.
  • Pregnancies identified by prenatal serum screening to be at increased risk for neural tube defects or chromosome defects.
Specimen Requirements 20 to 30 ml amniotic fluid collected in 2 to 3 sterile tubes. The first few mls of fluid should be discarded as they increase the likelihood of maternal cell contamination. The following information should accompany the specimen: patient's name, physician's name, date collected, EGA by ultrasound, LMP (if available), maternal age, and indication for study. Sterile tubes and mailers are available from the Greenwood Genetic Center. Cultured flasks may also be sent. Please send 2x T25 confluent flasks
Transport Specimen should be kept at room temperature; do not freeze or refrigerate. Specimen should be sent by courier or overnight mail to arrive at the laboratory within 24 hours.
Turnaround time 14 days. Cell culture can take 1-4 weeks and may lengthen turnaround time. Aneuvysion FISH results are usually available within 1-2 days
CPT Codes Chromosomes: 88235, 88269, 88280, 88285, 88291
FISH Trisomy Screen: 88235, 88275, 88271x4, 88291
Cost Chromosomes: $1256
FISH Trisomy Screen: $1094
Contact For further information contact Kellie King, MS , Lab Counselor or Barb DuPont,PhD, Cytogenetics Laboratory Director at 1-800-473-9411

Form Needed

Download ggc cyto-request-form - writable.pdf

Have Questions Need Support?

Contact our Laboratory Representative for assistance.
Kellie King, MS, CGC

Cytogenetics Lab

The Cytogenetics Lab provides high quality analysis for the detection of both constitutional chromosomal aberrations as well as abnormalities related to hematological malignancies

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