Clinical Genetics Residency

Director – David Everman, MD

The clinical genetics residency at the Greenwood Genetic Center is designed to provide intensive postgraduate clinical experience with heritable
or potentially heritable conditions. Residents are required to have completed a primary care residency program (family practice, internal medicine,
OB/GYN or pediatrics) in the United States. Clinical training includes exposure to prenatal, pediatric and adult genetics and counseling (2,500 new
families per year). Specifically, the resident will see a wide range of heritable disorders, reviewing the evaluation and management of each patient
with their preceptor. The student will learn principles of heredity through conferences, internal graduate courses and clinical experience. Moreover
they will study the nature of genetic disorders and their impact on the individual, family, and society.

The writing of case reports and reviews, utilization of genetic literature and the preparation of lectures will be integral parts in the residency learning
process. All residents are required to take a core course in Advanced Human Genetics through the Center.

While many heritable disorders have medical impact, the content and focus of the clinical residency at the Greenwood Genetic Center will be weighted toward
birth defects and intellectual disability. Comprehensive prenatal, pediatric and adult patient genetic evaluations are provided to the upstate region
of South Carolina through offices in Greenwood and Greenville. Experience with individuals and families having intellectual disability will be largely
gained through patients of the South Carolina Department of Disabilities and Special Needs in statewide outreach clinics. Experience in dysmorphology
will be obtained in the multiple regional and statewide outreach clinics. Additionally, the resident will have in-patient consults through Self Regional
Healthcare and prenatal experience through the Greenville Maternal-Fetal Medicine Program, Greenville and Greenwood Ob/Gyn, to gain experience in prenatal
and neonatal diagnostics, and the care and management of genetic disease.

The resident will also obtain laboratory and fetal pathology experience in the Anatomical Studies Section of the J. C. Self Research Institute of Human
Genetics. Rotation in fetal pathology is designed to improve the residents ability to recognize and evaluate malformations and other abnormalities
of human development. The student will gain practical experience in gross and microscopic study of specific fetal cases, for the purpose of diagnosis,
understanding of cause and management of recurrence risk issues and counseling. Monthly Fetal Boards take place through Greenville Memorial Hospital.
After successful completion of the residency program, the physician resident should be qualified for independent clinical practice in medical genetics
or an academic position in clinical genetics. The resident will be prepared to sit for the examination given by the American Board of Medical Genetics
for certification as a clinical geneticist.

Lab Rotations: Residents who will pursue the two-year genetic residency tract will arrange three 3-week rotations in each of our diagnostic laboratories:
molecular, biochemical and cytogenetics. The purpose of these rotations is to gain a more complete understanding of the diagnostic and research functions
of these laboratories in relation to clinical practice. The student will be expected to meet specific goals and objectives for each laboratory rotation.
For those residents choosing the three-year tract, the additional year can be spent as an elective in the research laboratories.

Research Elective: The J. C. Self Research Institute of Human Genetics, a division of the Greenwood Genetic Center, offers the resident an opportunity
for extensive research and training on molecular and anatomical approaches to birth defects and intellectual disability. Current research activities
of the faculty of the Research Institute include: localization, isolation, and characterization of genes responsible for X-linked intellectual disability;
mutation analysis of patients with X-linked hydrocephalus, Aarskog syndrome, EDA (ectodermal dysplasia); identification and characterization of genes
involved in lissencephaly, ectrodactyly and the BOR (branchial-oto-renal) syndrome; identification of candidate genes for neural tube defects and autism.

Library Access: The Center’s extensive English language library holdings contain over 1,000 monographs and pertinent genetics textbooks, including rare
and historical book collections in the area of birth defects. Over 60 current major Medical and Medical Genetics journals are in circulation as well
as a substantial number of back volumes for another 50 titles. The library also provides a comprehensive collection of patient photos, slides, and
radiographs from our clinical and research studies. A full-time librarian is on staff to assist in searches and interlibrary loans.

Didactic Teaching: Residents are required to participate in a regular set of conferences and lectures throughout the period of training. In addition, residents
have the opportunity to attend other seminars and lectures given through the Center. Required conferences are:

  • Journal Club 8:30 – 9:00 AM, Mondays – Brief review of current medical and genetics journals
  • Weekly Case Review 8:15-9:15 AM, Fridays – Clinical and research presentations
  • Advanced Human Genetics – Offered biannually
  • Statewide Genetics Case Review and Seminar – 10:00 AM – 1:00 PM, 4th Wednesday of each month. Review of patients seen on consultation; Seminar by faculty
    member or visiting faculty
  • Statewide Genetic Conclaves – Quarterly scientific and patient presentations

Application Process

Candidates for residency are expected to have completed a primary care residency program (family practice, internal medicine, OB/GYN or pediatrics) in
the United States. The candidate must also be licensed to practice medicine in the United States. Applications are handled through the Electronic Residency
Application Service (ERAS) site.

Application to the GGC residency program follows the deadlines of the ERAS site. Interviews are arranged and final decisions will be made as soon as possible.
Greenwood Genetic Center is an Equal Opportunity Employer. Women and interested minorities are encouraged to apply.

Laboratory Genetics and Genomics Fellowship

Director – Laura Pollard, PhD

Candidates with an M.D. or a Ph.D. degree in one of the basic sciences may enter this program. The Laboratory Genetics and Genomics (LGG) fellowship is
a three year program that allows the trainee to gain competence in performing and interpreting cytogenetic analysis relevant to the diagnosis and management
of chromosome disorders, as well as in all molecular analyses relevant to the diagnosis of genetic disorders at the gene level. The trainee will also
gain research experience by participating in on-going research projects and by conducting independent research.

Training is conducted through both the DNA Diagnostic and Cytogenetics Laboratories of the Greenwood Genetic Center. The DNA Diagnostic Laboratory handles
blood, amniocytes and CVS tissue samples for molecular analysis. The trainee will gain expertise in DNA and RNA isolation, PCR, Southern blotting,
RFLP analysis, Multiplex Ligation-Dependent Probe Amplification (MLPA), Pyrosequencing, and DNA sequencing – both Sanger and NextGen. The Cytogenetics
Laboratory provides training in routine G-banded analysis, special staining such as C-banding, silver staining, R-banding, and Q-banding, fluorescence
in situ hybridization (FISH) and array CGH for the diagnosis of microdeletion and microduplication syndromes, the detection of aneuploidy in uncultured
cells, and the identification of marker chromosomes.

At completion of the program, LGG Fellows will possess the skills required for certification by the ABMGG, including competence in:

  • Supervising and directing the operations of a clinical cytogenetics and/or molecular genetics diagnostic laboratory, including technical experience
    and knowledge in quality control and quality assessment procedures.
  • Performing a variety of cytogenetic and molecular diagnostic assays;
  • Understanding of the heterogeneity, variability, and natural history of chromosome and molecular genetic disorders;
  • Diagnostic and interpretive skills in a wide range of clinical molecular genetics and cytogenetics problems.
  • Communicating molecular and cytogenetic diagnostic laboratory results in the capacity of a consultant to medical genetics professionals and other clinicians,
    and directly to patients in concert with other professional staff.

By attending weekly clinic conference, weekly laboratory conference, and monthly state-wide case review, the trainee will interact with clinical geneticists,
genetic counselors and others who refer patients for cytogenetic and/or molecular testing. This interaction will allow discussion of pertinent clinical
features corresponding with laboratory findings and will permit the opportunity for discussion of counseling issues such as long term prognosis, family
studies, recurrence risks, and additional laboratory testing. In addition, the trainee is required to participate in a core course in Advanced Human
Genetics by attending all lectures and by limited teaching responsibilities.

Application Process

Applications for the 2021 Fellowship Program are currently closed.

Applications for the 2022 Fellowship Program are due by August 1, 2021 and should include the application form,
CV, statement of intent, and three letters of recommendation. Materials should be submitted via email to Leta Tribble, PhD.

Meet our trainees

Kameryn Butler, PhD – LGG Fellow

Xiaolan “Alice” Fang, PhD – LGG Fellow

Jiyong Wang, PhD – LGG Fellow

 

Training Program FAQs

Meet Reggie Roper

Reggie has been part of the GGC family for over 18 years. He has short stature, webbing of his hands, pulmonary stenosis, seizures and hydrocephalus along with developmental delay. He carried an initial diagnosis of cardiofaciocutaneous (CFC) syndrome; however, as genetic testing advanced, GGC made the diagnosis of Noon...

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