Pregnancy Loss Microarray

Test Information

The pregnancy loss microarray is performed using either Affymetrix CytoScan HD or OncoScan. This analysis can detect abnormalities such as aneuploidy, mosaicism as low as 20%, common microdeletion and microduplication syndromes, interstitial and terminal chromosome deletions and duplications greater than >300 kb, and loss of heterozygosity and suspected uniparental disomy (UPD).

Turnaround Time

26 days

CPT Code(s)




Clinical Information

Pregnancy loss occurs in up to 15% of all recognized pregnancies. In approximately half of these cases, the loss can be attributed to the presence of one or more chromosome abnormalities. The pregnancy loss microarray is performed using either Affymetrix CytoScan HD or OncoScan, and the appropriate platform will be determined by sample type and condition. This analysis can detect the following abnormalities: Aneuploidy Mosaicism as low as 20% Common microdeletion and microduplication syndromes Interstitial and terminal chromosome deletions and duplications greater than >300 kb Loss of heterozygosity and suspected uniparental disomy (UPD) If a maternal sample is also sent to the laboratory, maternal cell contamination can be detected, and the parent of origin for uniparental isodisomy can be determined.


Pregnancy loss microarray can be performed on fetal samples following miscarriage, fetal demise, or stillbirth.

Specimen Requirements

Fresh tissue (fetal tissue, amnion, placenta) Cultured cells Formalin fixed paraffin embedded (FFPE) Products of Conception should be placed in a sterile container for transport. The specimen must be kept moist, so add tissue culture media or sterile saline if needed. Fresh tissue: Using sterile technique, obtain a 5 mm biopsy of unmacerated fetal tissue and place in tube containing transport media. If tissue culture media is not available, sterile solutions such as balanced salt solution may be used. The preferred placental tissues are fetal membranes or chorionic villi. If fetal samples are obtained at autopsy, lung, gonad or thymus are preferred for chromosome study. Cultured tissue: 2-T25 confluent flasks can be sent for analysis. Extracted DNA is also accepted for this test. Please note that a maternal sample (4-5 ml of blood collected in a lavender-top/EDTA tube) is strongly recommended to rule out the presence of maternal cell contamination in POC samples. Additional specimen types include: saliva and extracted DNA. An additional charge ($350) will apply.

Transport Instructions

The specimen should be kept at room temperature and delivered via overnight shipping. Do not freeze.

Have Questions? Need Support?

Call our laboratory at 1-800-473-9411 or contact one of our Laboratory Genetic Counselors for assistance.
Robin Fletcher, MS, CGC
Falecia Thomas, MS, CGC

Meet Jeremiah

Play peek-a-boo with 9 month-old Jeremiah Licorish of Florence, and you'll be rewarded with a huge grin that lights up both his and his mother's faces. But this family has been through the unthinkable over the past few months, with very few reasons to smile. At first things were going well. Jeremiah was a happy, healthy newborn, doted on by his mother, Aneesa, and his three big brothers. But when Jeremiah was around 5 months old, Aneesa noticed ...

In The News