Trisomy FISH Screen (13,18,21,X,Y) (Chorionic Villus Sampling (CVS))

Trisomy Screen FISH analysis is a cytogenetic test used to identify aneuplodies involving chromosomes 13, 18, 21, X, and Y.

Turnaround Time

4 days

CPT Code(s)

88235, 88275 x2, 88271 x4, 88291

Cost

$1372

• Trisomy 13
• Trisomy 18
• Trisomy 21 also Down syndrome

The trisomy screen can be used as a rapid initial screen for some of the more common aneuploidies. FISH should be used in conjunction with G-banded chromosome analysis.

FISH: Fluorescence in situ hybridization is a molecular cytogenetic technique in which fluorescently labeled DNA probes are hybridized to metaphase spreads or interphase nuclei.

• Prenatal Microarray
• Chromosome Analysis, Routine (Chorionic Villus Sampling (CVS))
• Chromosome Analysis, Routine; Short Study (Chorionic Villus Sampling (CVS))

FISH can be performed on any tissue that can be cultured for chromosome analysis, including blood, fibroblasts, amniotic fluid, and chorionic villus sampling. Follow collection and transport guidelines specific for each tissue type. Studies requested should be indicated at the time of sample submission.

CVS: Specimen should be kept at room temperature; do not freeze or refrigerate. Specimen should be sent by courier or overnight mail to arrive at the laboratory the next day.