Periodic fevers are a heterogeneous group of conditions that are associated with variability in age of onset, severity, presentation, frequency, and duration of episodes. These episodes may be triggered by exposure to cold, illness or infection, stress, and overexertion. In addition to fever, common features include joint and muscle pain, rash or acne, conjunctivitis, swollen lymph nodes, abdominal pain, and pleuritis. Laboratory evidence of illness is typically present and may include increased sedimentation rate, leukocytosis, anemia, and neutropenia. Some patients experience kidney problems that can lead to kidney failure, and hepatosplenomegaly may occur. Uncommon findings limited to specific types of periodic fever can include dysmorphic features, contractures, growth abnormalities, seizures, hearing and vision loss, cardiomyopathy, and developmental delay. Most forms of periodic fever are inherited in an autosomal dominant pattern, but some appear to be autosomal recessive.